Acute Leukemias: Pharmacokinetics and Management of Relapsed by A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. PDF

By A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Priv. Doz. Dr. B. Wörmann, Prof. Dr. W. Plunkett, Prof. Dr. M. Keating, Prof. Dr. M. Andreeff (eds.)

ISBN-10: 3540539492

ISBN-13: 9783540539490

ISBN-10: 3642765912

ISBN-13: 9783642765919

This can be the 3rd quantity during this sequence on equipment of treating acute leukemia. a number of drug resistance is mentioned, in addition to using human granulocyte-macrophage CSF, the position of stem mobilephone issue, and simple points of mobile biology and pharmakokinetics. there's additionally a finished part facing relapse treatment and postremission remedy. The e-book hence offers the clinician with instructions to be used in daily perform.

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Additional info for Acute Leukemias: Pharmacokinetics and Management of Relapsed and Refractory Disease

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Third, by using an inhibitor of Pgp like verapamil, it may also be possible to assess the functional status of Pgp in the cells and consequently distinguish between cells expressing either at-MDR or PgpMDR. Such distinctions may allow us to determine whether these two forms of MDR are expressed in tumors and whether these phenotypes have relevance to the chemotherapeutic responsiveness of the patient. Accordingly, we have modified an assay that quantitates drug-stimulated topoisomerase II-DNA complexes in intact tumor cells [21, 22].

J Clin Oncol3: 1545-1522 Assaraf YG, Molina A, Schimke RT (1989) Cross resistance to the lipid soluble antifolate trimetrexate in human carcinoma cells with the multidrug resistant phenotype. J N C I 81: 290-294 Assaraf YG, Schimke RT (1987) Identification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometry. Proc Natl Acad Sci USA 84: 7154-7158 Wright JE, Rosowsky A, Boeheim K, Cucchi CA, Frei E III (1987) Flow cytometric studies of methotrexate resistance in human squamous carcinoma cell cultures.

Kuwazuru Y, Hanada S, Furukawa T, et al. (1990) Expression of P-glycoprotein in adult T-cell leukemia cells. Blood 76: 2065-2071 24. Kato S, Nishimura J, Muta K,Yufu Y, Nawata H, Ideguchi H (1990) Overexpression of P-glycoprotein in adult T-cell leukemia. Lancet 336: 573 25. Redner A, Hegewisch S, Haimi J, Stinherz P, Jhanwar S, Andreeff M (1990) A study of multidrug resistance and cell kinetics in a child with nearhaploid acute lymphoblastic leukemia. Leuk Res 14: 771-778 26. Kokenberg E, Sonneveld P, Delwel R, Sizoo W, Hagenbeek A, Lowenberg B (1988) In vivo uptake of daunorubicin by acute myeloid leukemia (AML) cells measured by flow cytometry.

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Acute Leukemias: Pharmacokinetics and Management of Relapsed and Refractory Disease by A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Priv. Doz. Dr. B. Wörmann, Prof. Dr. W. Plunkett, Prof. Dr. M. Keating, Prof. Dr. M. Andreeff (eds.)


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