Read e-book online Analysis of Aggregates and Particles in Protein PDF

By Hanns-Christian Mahler, Wim Jiskoot

ISBN-10: 0470497181

ISBN-13: 9780470497180

ISBN-10: 1118150570

ISBN-13: 9781118150573

Content material:
Chapter 1 The serious want for powerful Assays for Quantitation and Characterization of Aggregates of healing Proteins (pages 1–7): John F. chippie, Barry Cherney and Amy S. Rosenberg
Chapter 2 Separation?Based Analytical equipment for Measuring Protein Aggregation (pages 9–36): Jun Liu, Barthelemy Demeule and Steven J. Shire
Chapter three Laser gentle Scattering?Based concepts Used for the Characterization of Protein Therapeutics (pages 37–60): John den Engelsman, Fabian Kebbel and Patrick Garidel
Chapter four on-line Detection equipment and rising thoughts for Soluble Aggregates in Protein prescribed drugs (pages 61–84): Tapan ok. Das
Chapter five Analytical how you can degree Subvisible Particulates (pages 85–115): Shawn Cao, Linda Narhi, Yijia Jiang and Rahul S. Rajan
Chapter 6 Detection of noticeable debris in Parenteral items (pages 117–132): Ronald Smulders, Hans Vos and Hanns?Christian Mahler
Chapter 7 Characterization of Aggregates and debris utilizing rising recommendations (pages 133–167): Hui Zhao, Manuel Diez, Atanas Koulov, Mariola Bozova, Markus Bluemel and Kurt Forrer
Chapter eight Ultraviolet Absorption Spectroscopy (pages 169–200): Reza Esfandiary and Charles Russell Middaugh
Chapter nine Fluorescence Spectroscopy to symbolize Protein Aggregates and debris (pages 201–226): Robert A. Poole, Andrea Hawe, Wim Jiskoot and Kevin Braeckmans
Chapter 10 Infrared Spectroscopy to symbolize Protein Aggregates (pages 227–248): Marco van de Weert and Lene Jorgensen
Chapter eleven Raman Microscopy for Characterization of debris (pages 249–267): Stefan Fischer, Oliver Valet and Markus Lankers
Chapter 12 Microscopic equipment for Particle Characterization in Protein prescription drugs (pages 269–302): Patrick Garidel, Andrea Herre and Werner Kliche
Chapter thirteen comparability of equipment for Soluble combination Detection and measurement Characterization (pages 303–333): John S. Philo
Chapter 14 Protein Purification and its Relation to Protein Aggregation and debris (pages 335–367): Roberto Falkenstein, Stefan Hepbildikler, Wolfgang Kuhne, Thorsten Lemm, Hans Rogl, Eva Rosenberg, Gerhard iciness, Frank Zettl and Ralf Zippelius
Chapter 15 formula improvement and its Relation to Protein Aggregation and debris (pages 369–387): Miriam Printz and Wolfgang Friess

Show description

Read Online or Download Analysis of Aggregates and Particles in Protein Pharmaceuticals PDF

Similar industrial & technical books

High Energy Materials: Propellants, Explosives and - download pdf or read online

Propellants, explosives and pyrotechnics - or excessive strength fabrics (HEMs) to take advantage of an umbrella time period - have visible functions within the army zone, yet is also utilized in a number of methods in civilian parts resembling mining, development or spacecraft engineering. the invention of latest explosives within the Eighties boosted examine and improvement and prepared the ground for a scientific, practical synthesis of excessive strength fabrics.

Read e-book online Brewing (RSC Paperbacks) PDF

It's believed that beer has been produced, in a few shape, for millions of years - the traditional Egyptians being one civilization with an information of the fermentation strategy. Beer creation has obvious many adjustments over the centuries, and Brewing combines either an historic examine the method with a few up to date advancements.

Methanol Production and Use (Chemical Industries, Volume 57) - download pdf or read online

This paintings info the technical, environmental and company features of present methanol construction approaches and provides fresh advancements about the use of methanol in transportation gasoline and in agriculture. it truly is written through the world over popular methanol specialists from academia and undefined.

Additional info for Analysis of Aggregates and Particles in Protein Pharmaceuticals

Example text

Therefore, obtaining high precision requires careful maintenance of the instrumentation as well as additional steps to minimize both systematic and random noise. The wavelength and radial position accuracy as well as rotor temperature should be checked and calibrated regularly using reference or internal standards to ensure that the instrument is performing properly. The alignment of the AUC cell with the center of rotation can also be a factor [34]. An alignment tool can be used to improve the precision and accuracy of measurements.

The effect of a point mutation on the stability of IgG4 as monitored by analytical ultracentrifugation. J Pharm Sci 2008;97:960–969. 11. Liu D, Ren D, Huang H, Dankberg J, Rosenfeld R, Cocco MJ, Li L, Brems DN, Remmele RL Jr. Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation. Biochemistry 2008;47:5088–5100. 12. Narhi LO, Jiang Y, Cao S, Benedek K, Shnek D. A critical review of analytical methods for subvisible and visible particles. Curr Pharm Biotechnol 2009;10:373–381.

Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products. J Pharm Sci 2010;99:2200–2208. 6. Singh M, Chakrapani A, D O’Hagan. Nanoparticles and microparticles as vaccine delivery systems. Expert Rev. Vaccines 2007;6:797–808. 7. Chi EY, Weickmann J, Carpenter JF, Manning MC, Randolph TW. Heterogeneous nucleation-controlled particle formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation.

Download PDF sample

Analysis of Aggregates and Particles in Protein Pharmaceuticals by Hanns-Christian Mahler, Wim Jiskoot


by William
4.2

Rated 4.19 of 5 – based on 34 votes