By Antje Sander, Stefan Schwarz
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Additional info for Anatomie fast. Der Crashkurs
Mechanisms that mediate such e ects are important because they prevent overstimulation that could lead to cellular damage or adversely a ect the organism as a whole. Many drugs show diminishing e ects over time; this phenomenon is called tachyphylaxis . In pharmacologic terms, the receptor and the cell become desensitized to the action o the drug. Mechanisms o desensitization can be divided into two types: homologous , in which the e ects o agonists at only one type o receptor are diminished, and heterologous , in which the e ects o agonists at two or more types o receptors are coordinately diminished.
The transcription o DNA into RNA and the translation o RNA into protein are controlled by a diverse set o molecules. Transcription o many genes is regulated, in part, by the interaction between lipid-soluble signaling molecules and transcription regulatory actors. Because o the undamental role played by control o transcription in many biological processes, transcription regulators (also called transcription factors ) are the targets o some important drugs. Steroid hormones are a class o lipophilic drugs that di use readily through the plasma membrane and act by binding to transcription actors in the cytoplasm or nucleus (Fig.
Bindin bindd in g Partial binding b bind i n d i n g Agonists. . . . . . . . . . . . . . . . . . . . 23 DOSE–RESPONSE RELA ATI TIONSHIPS . . . . . . . . . . . . 18 Graded Dose–Respponnse s e Relat elatiionships . . . . . . . . . . 18 Quan Qu anta tall Dose–Response Re Rela lationships . . . . . . . . . . 19 DRUG–RECEPTOR INTERACTIONS . . . . . . . . . . . . . 20 A i t . . . . . . . . . . . . . . . . . . . .
Anatomie fast. Der Crashkurs by Antje Sander, Stefan Schwarz