Read e-book online Arterial Stiffness: Implications and Interventions PDF

By Bradley S. Fleenor, Adam J. Berrones

ISBN-10: 3319248421

ISBN-13: 9783319248424

ISBN-10: 3319248448

ISBN-13: 9783319248448

Arterial stiffness is an rising threat issue with vital implications for heart problems threat. Herein, we concisely summarize the physiological and pathophysiological elements of arterial stiffening, and spotlight the significance of elevated arterial stiffness for destiny cardiovascular occasions. elements contributing to elevated arterial stiffness resembling advancing age, weight problems, race, intercourse alterations and cardiorespiratory health are tested whereas elucidating the aptitude underlying mechanisms for every situation. To finish, we talk about novel interventions to avoid and/or opposite the arterial stiffening technique on the way to lessen cardiovascular danger.

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Extra info for Arterial Stiffness: Implications and Interventions

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05674 32. Fleenor BS, Marshall KD, Rippe C, Seals DR (2012) Replicative aging induces endothelial to mesenchymal transition in human aortic endothelial cells: potential role of inflammation. J Vasc Res 49(1):59–64. 1159/000329681 33. Hamilton CA, Brosnan MJ, McIntyre M, Graham D, Dominiczak AF (2001) Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. Hypertension 37(2 pt 2):529–534 34. Tan Y, Tseng PO, Wang D, Zhang H, Hunter K, Hertzberg J, Stenmark KR, Tan W (2014) Stiffening-induced high pulsatility flow activates endothelial inflammation via a TLR2/ NF-kappaB pathway.

Similarly, the SardiNIA showed that B-PP increased for both men and women at the entry age of 55 years, however for men the increase was attenuated until 70 years, which there was little change in B-PP after this age [25]. In contrast to men, the average longitudinal rate of change of B-PP for women continued to increase (monotonically) with every decade from age of 30 to beyond 70 years. In short, both B-PP and C-PP in women have shown to increase with advancing age compared with men [25, 30], indicating central blood pressure is a key target to reduce CVD risk in older women.

However, reports have suggested strength training may increase measures of arterial stiffness. For example, Bertovic et al. [56] compared apparently 34 3 Implications of Arterial Stiffness healthy young males who had regularly strength trained for 12 months to sedentary controls, and discovered that strength trained athletes had higher aortic characteristic impedance and β stiffness. Additionally, strength trained athletes had greater carotid and brachial pulse pressures compared with the sedentary controls [56].

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Arterial Stiffness: Implications and Interventions by Bradley S. Fleenor, Adam J. Berrones


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