By Valentin Fuster MD PhD, Eric J. Topol MD, Elizabeth G. Nabel MD
Written through the world’s optimal professionals, this quantity presents finished assurance of present techniques to the prevention, analysis, and administration of atherothrombosis and its coronary and noncoronary issues. This version has been completely up to date, sharply all for medical info, and trimmed to at least one plausible volume.
Coverage starts off with a overview of chance components and prevention, emphasizing lipid abnormalities, high blood pressure, smoking, diabetes, and weight problems. next sections learn the pathogenesis of atherosclerosis, markers and imaging, acute coronary syndromes, continual solid angina, and noncoronary atherothrombosis. medical shows, scientific administration, and the most recent interventional thoughts are included.
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Additional info for Atherothrombosis and coronary artery disease
1–5). Hunter and Jenner found no abnormalities in the heart or other organs to explain the doctor’s death, however. Because of Heberden’s (as well as Hunter’s and Jenner’s) lack of recognition that coronary artery disease was the cause of angina, the anonymous doctor’s coronary arteries were not examined (26). After serving as Hunter’s assistant for two years, Jenner returned to his hometown of Gloucestershire to begin his career as a country doctor. Once in practice, Jenner saw more patients with angina.
Murrell became interested in nitroglycerin, a homeopathic remedy first used by Constantine Hering in the 1840s, because he found that its effect on heart rate and arterial tension was similar to that of amyl nitrite (31). Murrell found that nitroglycerin relieved angina promptly, although its effects came on more slowly and lasted longer than those of amyl nitrite. After Murrell’s 1879 report in the Lancet, nitroglycerin’s value in angina was rapidly and widely acknowledged. This was true, in large part, because its beneficial effects were immediate, dramatic, and reproducible.
Parry attributed angina to “induration” and “ossification” of the coronary arteries and proposed that they might be “so obstructed as to intercept the blood, which should be the proper support of the muscular fibres of the heart that [the] organ must become thin and flaccid, and unequal to the task of circulation” (28). Scottish anatomist and physician Allan Burns published the first English language book on heart disease in 1809. ” Burns drew an analogy between coronary artery disease and the ligation of a peripheral artery to support his view of the pathophysiology of angina pectoris (29).
Atherothrombosis and coronary artery disease by Valentin Fuster MD PhD, Eric J. Topol MD, Elizabeth G. Nabel MD