By M.J. Janse, M.R. Rosen (auth.)
This booklet contains the main up-to date info regarding mechanisms and therapy of cardiac arrhythmia. a few of the themes mentioned during this textual content replicate very lately undertaken learn instructions together with genetics of arrhythmias, mobilephone signalling molecules as capability healing ambitions and trafficking to the membrane. those new methods and implementations of anti-arrhythmic treatment derive from many many years of analysis as defined within the first bankruptcy by means of distinct Professors Michael Rosen (Columbia college) and Michiel Janse (University of Amsterdam). The textual content covers adjustments in methods to remedy through the years, arrhythmias in a number of cardiac areas and over many scales, from gene to protein to mobilephone to tissue to organ.
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Extra resources for Basis and Treatment of Cardiac Arrhythmias
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60 60 61 62 5 Conclusions . . . . . . . . . . . . . . . . . . 63 References . . . . . . . . . . . . . . . . . . . . 64 . . . . . . . . . . Abstract The ionic basis of automaticity in the sinoatrial node and His–Purkinje system, the primary and secondary cardiac pacemaking regions, is discussed. Consideration is given to potential targets for pharmacologic or genetic therapies of rhythm disorders. An ideal target would be an ion channel that functions only during diastole, so that action potential repolarization is not affected, and one that exhibits regional differences in expression and/or function so that the primary and secondary pacemakers can be selectively targeted.
Basis and Treatment of Cardiac Arrhythmias by M.J. Janse, M.R. Rosen (auth.)